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Clinician Article

Sling surgery for stress urinary incontinence in women: a systematic review and metaanalysis.



  • Schimpf MO
  • Rahn DD
  • Wheeler TL
  • Patel M
  • White AB
  • Orejuela FJ, et al.
Am J Obstet Gynecol. 2014 Jul;211(1):71.e1-71.e27. doi: 10.1016/j.ajog.2014.01.030. Epub 2014 Jan 30. (Review)
PMID: 24487005
Read abstract Read evidence summary
Disciplines
  • Gynecology
    Relevance - 7/7
    Newsworthiness - 6/7
  • Surgery - Urology
    Relevance - 5/7
    Newsworthiness - 4/7

Abstract

OBJECTIVE: Understanding the long-term comparative effectiveness of competing surgical repairs is essential as failures after primary interventions for stress urinary incontinence (SUI) may result in a third of women requiring repeat surgery.

STUDY DESIGN: We conducted a systematic review including English-language randomized controlled trials from 1990 through April 2013 with a minimum 12 months of follow-up comparing a sling procedure for SUI to another sling or Burch urethropexy. When at least 3 randomized controlled trials compared the same surgeries for the same outcome, we performed random effects model metaanalyses to estimate pooled odds ratios (ORs).

RESULTS: For midurethral slings (MUS) vs Burch, metaanalysis of objective cure showed no significant difference (OR, 1.18; 95% confidence interval [CI], 0.73-1.89). Therefore, we suggest either intervention; the decision should balance potential adverse events (AEs) and concomitant surgeries. For women considering pubovaginal sling vs Burch, the evidence favored slings for both subjective and objective cure. We recommend pubovaginal sling to maximize cure outcomes. For pubovaginal slings vs MUS, metaanalysis of subjective cure favored MUS (OR, 0.40; 95% CI, 0.18-0.85). Therefore, we recommend MUS. For obturator slings vs retropubic MUS, metaanalyses for both objective (OR, 1.16; 95% CI, 0.93-1.45) and subjective cure (OR, 1.17; 95% CI, 0.91-1.51) favored retropubic slings but were not significant. Metaanalysis of satisfaction outcomes favored obturator slings but was not significant (OR, 0.77; 95% CI, 0.52-1.13). AEs were variable between slings; metaanalysis showed overactive bladder symptoms were more common following retropubic slings (OR, 1.413; 95% CI, 1.01-1.98, P = .046). We recommend either retropubic or obturator slings for cure outcomes; the decision should balance AEs. For minislings vs full-length MUS, metaanalyses of objective (OR, 4.16; 95% CI, 2.15-8.05) and subjective (OR, 2.65; 95% CI, 1.36-5.17) cure both significantly favored full-length slings. Therefore, we recommend a full-length MUS.

CONCLUSION: Surgical procedures for SUI differ for success rates and complications, and both should be incorporated into surgical decision-making. Low- to high-quality evidence permitted mostly level-1 recommendations when guidelines were possible.


Clinical Comments

Gynecology

The design, objectives and inclusion criteria were very appropriate and useful. The study design (ORs) and (CI) allowed taking conclusions of great value. Conclusions are carried out upon the basis of 2.6% of the population, N49 from 72 articles. Adverse affects were analyzed from 704, that is to say 12% of the NRCTs. So 2.9% of the selected articles were valid to establish conclusions.

Gynecology

This is another meta analysis of the literature except with overt recommendations for procedural choice. The issues around mesh are not weighted in the ultimate recommendations.

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