Clinician Article

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

  • Grundy SM
  • Stone NJ
  • Bailey AL
  • Beam C
  • Birtcher KK
  • Blumenthal RS, et al.
J Am Coll Cardiol. 2019 Jun 25;73(24):e285-e350. doi: 10.1016/j.jacc.2018.11.003. Epub 2018 Nov 10. (Review)
PMID: 30423393

  • Family Medicine (FM)/General Practice (GP)
    Relevance - 7/7
    Newsworthiness - 6/7
  • General Internal Medicine-Primary Care(US)
    Relevance - 7/7
    Newsworthiness - 6/7
  • Endocrine
    Relevance - 7/7
    Newsworthiness - 5/7
  • Internal Medicine
    Relevance - 7/7
    Newsworthiness - 5/7
  • Cardiology
    Relevance - 6/7
    Newsworthiness - 4/7


This item does not have an abstract.

Clinical Comments


An important evidence-based update on the management of hypercholesterolemia!


Very detailed analysis and suggestions with more summary take-home messages that should be useful.


A useful and practical guide concentrating appropriately on the use of statins and their side effects. The CV risk threshold for statin introduction remains 7.5%. Quite a lot of the suggestions made are labelled as 'reasonable' - presumably meaning that the evidence is inconclusive. PCSK9 inhibitors (not available in my country) are still too expensive to win a recommendation. The evidence supporting greater use of coronary calcium studies is not clear.

General Internal Medicine-Primary Care(US)

This is the full set of guidelines for treating cholesterol that was published in August 2018 and is > 60 pages long. Pros: It is organized by patient risk category, it has all the evidence in one place, and it`s endorsed by just about every group out here. Cons: it is quite long and it may take a minute to locate the answer you want. Still, probably everyone should have this article bookmarked.

General Internal Medicine-Primary Care(US)

There was a synopsis of this in the Annals of Internal Medicine last month.

Internal Medicine

Guidelines are usually highly clinically relevant. This guideline is no exception given the broad-reaching topic and highly reputable sponsoring societies.

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