Clinician Article

Trial of Endovascular Thrombectomy for Large Ischemic Strokes.

  • Sarraj A
  • Hassan AE
  • Abraham MG
  • Ortega-Gutierrez S
  • Kasner SE
  • Hussain MS, et al.
N Engl J Med. 2023 Feb 10. doi: 10.1056/NEJMoa2214403. (Original)
PMID: 36762865
Read abstract
  • Neurology
    Relevance - 7/7
    Newsworthiness - 6/7
  • Emergency Medicine
    Relevance - 6/7
    Newsworthiness - 6/7
  • Hospital Doctor/Hospitalists
    Relevance - 6/7
    Newsworthiness - 5/7
  • Internal Medicine
    Relevance - 6/7
    Newsworthiness - 5/7


BACKGROUND: Trials of the efficacy and safety of endovascular thrombectomy in patients with large ischemic strokes have been carried out in limited populations.

METHODS: We performed a prospective, randomized, open-label, adaptive, international trial involving patients with stroke due to occlusion of the internal carotid artery or the first segment of the middle cerebral artery to assess endovascular thrombectomy within 24 hours after onset. Patients had a large ischemic-core volume, defined as an Alberta Stroke Program Early Computed Tomography Score of 3 to 5 (range, 0 to 10, with lower scores indicating larger infarction) or a core volume of at least 50 ml on computed tomography perfusion or diffusion-weighted magnetic resonance imaging. Patients were assigned in a 1:1 ratio to endovascular thrombectomy plus medical care or to medical care alone. The primary outcome was the modified Rankin scale score at 90 days (range, 0 to 6, with higher scores indicating greater disability). Functional independence was a secondary outcome.

RESULTS: The trial was stopped early for efficacy; 178 patients had been assigned to the thrombectomy group and 174 to the medical-care group. The generalized odds ratio for a shift in the distribution of modified Rankin scale scores toward better outcomes in favor of thrombectomy was 1.51 (95% confidence interval [CI], 1.20 to 1.89; P<0.001). A total of 20% of the patients in the thrombectomy group and 7% in the medical-care group had functional independence (relative risk, 2.97; 95% CI, 1.60 to 5.51). Mortality was similar in the two groups. In the thrombectomy group, arterial access-site complications occurred in 5 patients, dissection in 10, cerebral-vessel perforation in 7, and transient vasospasm in 11. Symptomatic intracranial hemorrhage occurred in 1 patient in the thrombectomy group and in 2 in the medical-care group.

CONCLUSIONS: Among patients with large ischemic strokes, endovascular thrombectomy resulted in better functional outcomes than medical care but was associated with vascular complications. Cerebral hemorrhages were infrequent in both groups. (Funded by Stryker Neurovascular; SELECT2 ClinicalTrials.gov number, NCT03876457.).

Clinical Comments

Emergency Medicine

Adds to the increasing number of trials supporting thrombectomy for acute ischemic stroke - in this case within 24 hours of symptom onset.


Clearly this is a practice-changing clinical trial result. Along with previously published RCTs from Japan (RESCUE Japan LIMIT) and ANGEL-ASPECT from China published in the same issue of NEJM, the SELECT2 trial is convincing in expanding the indication for acute endovascular therapy for ischemic stroke. The study enrolled patients with large vessel occlusion with already relatively large core infarct, excluded from prior studies. There was benefit of reasonable effect size. Risk for harm was low.


Highly important trial pushing the envelope on the types of patients treated (large areas of damage) and wider time frame (up to 24h). This plus a similar trial reported in the same NEJM issue strongly supports increasing the eligibility for thrombectomy to large strokes in a wider time frame. Major advance.

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